{"id":89153,"date":"2024-02-26T04:12:00","date_gmt":"2024-02-26T07:12:00","guid":{"rendered":"https:\/\/bluestudio.estadao.com.br\/agencia-de-comunicacao\/releases\/releases-geral\/survodutide-phase-ii-trial-shows-83-of-adults-treated-achieved-groundbreaking-results-in-liver-disease-due-to-mash-with-significant-improvements-in-fibrosis\/"},"modified":"2024-02-26T04:12:00","modified_gmt":"2024-02-26T07:12:00","slug":"survodutide-phase-ii-trial-shows-83-of-adults-treated-achieved-groundbreaking-results-in-liver-disease-due-to-mash-with-significant-improvements-in-fibrosis","status":"publish","type":"post","link":"https:\/\/bluestudio.estadao.com.br\/agencia-de-comunicacao\/releases\/releases-geral\/survodutide-phase-ii-trial-shows-83-of-adults-treated-achieved-groundbreaking-results-in-liver-disease-due-to-mash-with-significant-improvements-in-fibrosis\/","title":{"rendered":"Survodutide Phase II trial shows 83% of adults treated achieved groundbreaking results in liver disease due to MASH, with significant improvements in fibrosis"},"content":{"rendered":"<p><b>Boehringer Ingelheim<\/b><\/p>\n<ul>\n<li>Survodutide has potential to become best-in-class treatment for metabolic dysfunction-associated steatohepatitis (MASH)*, after meeting its primary and key secondary endpoint following 48 weeks of treatment versus placebo in a Phase II trial<\/li>\n<li>Survodutide, a novel glucagon\/GLP-1 receptor dual agonist, has demonstrated efficacy in people with obesity<sup>1<\/sup>, and statistically significant results in MASH<sup>2<\/sup>\u00a0suggest the potential to lead to clinically meaningful benefits across the cardiovascular, renal, and metabolic spectrum<\/li>\n<li>Full data from the Phase II trial will be presented in the coming months<\/li>\n<\/ul>\n<p>Boehringer Ingelheim today announced that up to 83.0% of adults treated with survodutide (BI 456906) achieved a statistically significant improvement of metabolic dysfunction-associated steatohepatitis (MASH) versus placebo (18.2%) in a Phase II trial [response difference: 64.8% (CI 51.1% &#8211; 78.6%), p&lt;0.0001].<sup>2<\/sup>\u00a0The trial met its primary endpoint with survodutide reaching a biopsy-proven improvement in MASH after 48 weeks, without worsening of fibrosis stages F1, F2 and F3 (mild to moderate or advanced scarring).<sup>2<\/sup>\u00a0Survodutide also met all secondary endpoints, including a statistically significant improvement in liver fibrosis.<sup>2<\/sup>\u00a0Full data will be presented in the coming months.<\/p>\n<p>Survodutide has the potential to become a best-in-class treatment for MASH, a liver disease connected with other cardiovascular, renal, and metabolic conditions.<sup>3,4,6<\/sup><\/p>\n<p>Survodutide is a glucagon\/GLP-1 receptor dual agonist with a novel mechanism of action, and the first to show this level of benefit in a Phase II MASH trial.<sup>2,7<\/sup>\u00a0The glucagon agonist component in survodutide has the potential to increase energy expenditure,<sup>7<\/sup>and has a direct impact in the liver which potentially contributes to the improvement of fibrosis.<sup>2<\/sup>\u00a0The GLP-1 agonist component decreases appetite while increasing fullness and satiety.<sup>7,8<\/sup><\/p>\n<p>I am thrilled to see these statistically significant results from the Phase II trial of survodutide in MASH and fibrosis. These data position survodutide as a potential leading treatment for a population with great unmet medical needs, and will bring hope to people living with MASH and with fibrosis, said Dr. Arun Sanyal, M.D., Professor of Medicine, Physiology and Molecular Pathology at Virginia Commonwealth University School of Medicine, and Principal Investigator of the trial. I am looking forward to sharing further detail on key secondary endpoints, including the percentage of adults who saw an improvement in fibrosis, at a congress in the first half of this year.<\/p>\n<p>These MASH results show survodutide has potential to become a best-in-class treatment, and we believe its true differentiator is the action of the glucagon receptor agonism which works directly on the liver, said Carinne Brouillon, Head of Human Pharma, Boehringer Ingelheim. In order to bring this potential treatment to the more than 1 billion people affected by interconnected cardiovascular, renal, metabolic diseases, we will move forward as quickly as possible in MASH. We are also progressing with survodutide in other related conditions, having already initiated our Phase III clinical trial program for obesity.<\/p>\n<p>The liver governs the bodys metabolism and consequently plays an important role in the cardiovascular, renal and metabolic system.<sup>9<\/sup>\u00a0MASH is a progressive disease impacting more than 115 million people worldwide<sup>10<\/sup>,\u00a0caused by inflammation of the liver\u00a0that can lead to fibrosis.<sup>11<\/sup>\u00a0Severe tissue scarring in the liver (cirrhosis) can substantially increase the risk of end-stage liver disease and liver cancer,<sup>5<\/sup>\u00a0\u00a0for which a liver transplant may be the only treatment option.<sup>12<\/sup>\u00a0MASH is predicted to be the leading cause of liver transplantation by 2030,<sup>13<\/sup>\u00a0placing significant financial strain on healthcare systems.<sup>14,15<\/sup>\u00a0MASH can also impact a persons quality of life, relationships, and capacity to work.<sup>16<\/sup>\u00a0Despite these burdens, targeted therapies are lacking and there are currently no approved licensed medicines.<\/p>\n<p>The double-blind, placebo-controlled Phase II trial studied three doses of survodutide at 2.4 mg, 4.8 mg, and 6.0 mg.<sup>17<\/sup>\u00a0Top-line results demonstrated an improvement in MASH, at all doses explored in the trial.<sup>2<\/sup> Treatment with survodutide did not show unexpected safety or tolerability issues, including at the higher dose of 6.0mg.<sup>2<\/sup><\/p>\n<p>Todays news builds on U.S. Food and Drug Administration (FDA) Fast Track Designation for survodutide in 2021,<sup>18<\/sup>\u00a0followed by the European Medicines Agency (EMA) granting access for survodutide to the Priority Medicine (PRIME) Scheme for MASH with fibrosis in November last year.19\u00a0These processes are designed to help expedite the review of drugs to treat serious conditions and fill an unmet need, with the intention of bringing important new drugs to patients earlier.\u00a0<\/p>\n<p>Survodutide is also being evaluated in five Phase III studies for people living with overweight and obesity, among key sub-populations.<sup>20<\/sup>\u00a0SYNCHRONIZE-1 and SYNCHRONIZE-2 sub-populations include people living with comorbidities, without and with type 2 diabetes, respectively.<sup>20<\/sup>\u00a0The SYNCHRONIZE-CVOT trial sub-population includes people living with cardiovascular disease, chronic kidney disease, or with risk factors for cardiovascular disease.<sup>20<\/sup>\u00a0As well as this, Boehringer Ingelheim is exploring survodutide in Phase III trials in Japan (SYNCHRONIZE-JP) and in China (SYNCHRONIZE-CN) for sub-populations of people living with obesity.<sup>21,22<\/sup><\/p>\n<p><b><strong>Use of MASH terminology<\/strong><\/b><\/p>\n<p>*Boehringer Ingelheims Phase II trial is registered on clinicaltrials.gov as A Study to Test Safety and Efficacy of BI456906 in Adults With Non-alcoholic Steatohepatitis (NASH) and Fibrosis (F1-F3).<\/p>\n<p>This trial was registered prior to a 2023 update in nomenclature made by a number of multinational liver societies including EASL, AASLD and ALEH.<sup>23<\/sup>\u00a0Their recommendation was to update non-alcoholic fatty liver disease (NAFLD) to metabolic dysfunction-associated steatotic liver disease (MASLD), and to update non-alcoholic steatohepatitis (NASH) with metabolic dysfunction-associated steatohepatitis (MASH).<sup>23<\/sup><\/p>\n<p>The global liver community stated that the name changes reflect an affirmative, non-stigmatizing name and diagnosis that can be used around the world to improve research and funding into these conditions.<sup>23<\/sup>\u00a0An independent committee of experts external to this process made the final recommendations of the acronyms.<sup>23<\/sup><\/p>\n<p>To reflect these recommendations, Boehringer Ingelheim has adopted the use of MASH to describe this Phase II trial.<\/p>\n<p><b>About metabolic dysfunction-associated steatohepatitis (MASH)<\/b><\/p>\n<p>MASH is a chronic and progressive liver disease caused by a build-up of fat in the liver,<sup>11,24,25<\/sup>\u00a0and is a more severe form of metabolic dysfunction-associated steatotic liver disease (MASLD).<sup>26<\/sup>\u00a0Approximately 20-30% of people living with MASLD go on to develop MASH,<sup>27<\/sup>\u00a0and the number of MASH cases is predicted to rise by 63% between 2015 and 2030, from 16.5 million to 27.0 million cases.<sup>12<\/sup>\u00a0MASH is a disease closely associated with connected cardiovascular, renal, and metabolic diseases,<sup>6,28<\/sup>\u00a0and it is estimated that 34% of people living with obesity also have MASH.<sup>29<\/sup>\u00a0MASH also represents the fastest growing cause for liver transplantation in Western countries.<sup>14<\/sup><\/p>\n<p>MASH severity is assessed using a scale that ranges from F0 to F4, which measures the level of fibrosis (scarring):<sup>30<\/sup><\/p>\n<ul>\n<li>F0-F1: indicates no or mild fibrosis<\/li>\n<li>F2-3: indicates moderate or advanced fibrosis<\/li>\n<li>F4: indicates cirrhosis<\/li>\n<\/ul>\n<p><b><strong>About the trial (NCT04771273)<\/strong><\/b><\/p>\n<p>This is a Phase II, randomized double-blind placebo-controlled dose-finding trial of 295 participants that evaluates weekly subcutaneous injections of survodutide in people living with MASH and fibrosis (F1-F3) among adults both with and without type 2 diabetes.<sup>17<\/sup><\/p>\n<p>The primary endpoint of trial is the percentage of participants achieving histological improvement of MASH without worsening of fibrosis after 48 weeks of treatment.<sup>17<\/sup>\u00a0A histological improvement of MASH is defined as a decrease of 2 \u00a0points on the Non-alcoholic Fatty Liver Disease Activity Score (NAS  total score ranges from 0-8), including 1 point decrease in NASH sub-score for lobular inflammation or ballooning, and no increase in fibrosis stage.<sup>17<\/sup>\u00a0The NAS represents the sum of scores for steatosis (a build-up of fat in the liver<sup>31<\/sup>), lobular inflammation (inflammatory cells<sup>32<\/sup>) and ballooning (a type of liver cell degeneration<sup>33<\/sup>).<\/p>\n<p>Secondary outcome measures include:<sup>17<\/sup><\/p>\n<ul>\n<li>At least 30% relative reduction in liver fat content after 48 weeks of treatment compared to baseline<\/li>\n<li>Absolute and relative change of liver fat content from baseline after 48 weeks of treatment<\/li>\n<li>Improvement of fibrosis, defined as at least one stage decrease in fibrosis stage after 48 weeks of treatment<\/li>\n<li>Absolute change from baseline in total score for NAS after 48 weeks of treatment<\/li>\n<\/ul>\n<p>The trial consisted of dose escalation to either 2.4mg, 4.8mg and 6.0mg treatment groups for up to 24 weeks, and dose maintenance for 24 weeks.<sup>17<\/sup><\/p>\n<p><b><strong>About survodutide (BI 456906)<\/strong><\/b><\/p>\n<p>Survodutide is a glucagon\/GLP-1 receptor dual agonist that activates both the glucagon and GLP-1 receptors, which are critical to controlling metabolic functions.<sup>7<\/sup>\u00a0Co-invented by Boehringer Ingelheim and Zealand Pharma, survodutide is part of Boehringer Ingelheims research and development portfolio in the cardiovascular, renal, and metabolic disease areas.<\/p>\n<p>Survodutide was granted U.S. FDA Fast Track Designation in May 2021 for the treatment of MASH and fibrosis,<sup>18<\/sup>\u00a0and it was accepted to the EMA PRIME scheme in November 2023.<sup>19<\/sup><\/p>\n<p>Boehringer is also studying survodutide in a 2-part Phase I trial among people cirrhosis (F4) and varying degrees of liver dysfunction.<sup>34<\/sup>\u00a0The purpose of Part 1 is to find out whether cirrhosis (F4) and varying degrees of liver dysfunction influences how\u00a0survodutide is taken up in the body, and the purpose of Part 2 is to find out whether having cirrhosis (F4) and varying degrees of liver dysfunction influences how people with overweight and obesity tolerate survodutide treatment for 28 weeks.<sup>34<\/sup><\/p>\n<p>Survodutide is also being evaluated in five Phase III studies (SYNCHRONIZE-1, SYNCHRONIZE-2, SYNCHRONIZE-CVOT) for people living with overweight and obesity.<sup>20<\/sup>\u00a0Sub-populations for SYNCHRONIZE-1 and SYNCHRONIZE-2 include patients with comorbidities, without and with type 2 diabetes, respectively.<sup>20\u00a0<\/sup>The sub-population for SYNCHRONIZE-CVOT includes patients with cardiovascular disease, chronic kidney disease, or with risk factors for cardiovascular disease.<sup>20<\/sup>\u00a0As well as this, Boehringer Ingelheim is exploring survodutide in Phase III trials in Japan (SYNCHRONIZE-JP) and in China (SYNCHRONIZE-CN) for sub-populations of people living with obesity.21,22\u00a0Both trials explore the relative change in liver fat from baseline to week 76 when treated with survodutide versus placebo, as a key secondary endpoint.<sup>21,22<\/sup><\/p>\n<p><b>About Boehringer Ingelheim<\/b><\/p>\n<p>Boehringer Ingelheim is working on breakthrough therapies that transform lives, today and for generations to come. As a leading research-driven biopharmaceutical company, the company creates value through innovation in areas of high unmet medical need. Founded in 1885 and family-owned ever since, Boehringer Ingelheim takes a long-term, sustainable perspective. More than 53,000 employees serve over 130 markets in the two business units Human Pharma and Animal Health. Learn more at\u00a0<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=AM24b9t6E_-azcRiCnaCgtMQezjajZ18LMoHpn1SUP5f-h3SpPWzO12MGzskzrXTlMzhKl0zsc7gCwGVC-pLnjzJeyoDkR_6MAzz5q_qnlmewgJI4B6ZipDDuyUAVTcs\" rel=\"nofollow noopener\" target=\"_blank\">www.boehringer-ingelheim.com\/uk<\/a>\u00a0(UK and Ireland) or\u00a0<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=AM24b9t6E_-azcRiCnaCgtMQezjajZ18LMoHpn1SUP55EiXKaoj5Ra9OQfRtQNNK29awVQJpoiIyOa3eL5y_zq5xFxRauTxJ7W00wt8yzmSnD-jjBA3PQcUxqSmmEivK\" rel=\"nofollow noopener\" target=\"_blank\">www.boehringer-ingelheim.com<\/a>\u00a0(rest of world).\u00a0\u00a0<\/p>\n<p><b>Boehringer Ingelheims Intended Audiences Notice<\/b><\/p>\n<p>This press release is issued from our Corporate Headquarters in Ingelheim, Germany and is intended to provide information about our global business. Please be aware that information relating to the approval status and labels of approved products may vary from country to country, and a country-specific press release on this topic may have been issued in the countries where we do business.<\/p>\n<p>See the release\u00a0on the Boehringer Ingelheim&#8217;s\u00a0<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=pjYA50Xmdu9E-j8FPB2Ap7vN3q-q0DvcNeDQmmVO4UnogGykBYIK_5Bz-HNcCi16WytzXw3tdTNeQgs-DS_vRe5fSn1ylp1hpp8X2i9GhNGK7I9mha5Nbm2zJVTVANLfwCD35V7BT-OJ1llNASp0-1XBuMRlOFAhpK0jH8Y8ec8SMJQ6Oe9zaHEklOw0zp_ItPqwjLvf8tJ7NNi2apxpJQ==\" rel=\"nofollow noopener\" target=\"_blank\">website<\/a>.<\/p>\n<p><b><strong>References<\/strong><\/b><\/p>\n<p><sup>1<\/sup>Boehringer Ingelheim. Data shows nearly 19% weight loss in people with overweight or obesity in Boehringer Ingelheim and Zealand Pharma Phase II trial with survodutide. Available at:\u00a0<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=Rn_XD3LjfnRhRTY-r54hzTChANfs7agjFqmkrByqZ1fRWH8PYRxQGxKhqmzaGpYdywNvYq6y7SnFiUh-XtltCALsevIr9UTKYpny2R28NvLRKnb24G--7x5Wo6M139WH8ZjT1cY2p_GvWCj96iRlDr25IfuYWHV2hiT8cP9iOu19K8SFixotzmqrDVIWF7KRx9uQsCMf6FLOZk3958_NAQqiQ9W9ZrXEjRoAxomMOqM55fAW1f4k-n9DymxCfh3ykasMLcX6V7ismibJz3jkWaQ3BlHDCDrh4UNTKBAUJY8NAlE0Y-VcPPiIK4ysElzA-9VC5NB--m6c4vgxfY9_4PW8Np5TgB0pkzsQl-91DX0=\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/www.boehringer-ingelheim.com\/human-health\/metabolic-diseases\/obesity\/phase-ii-clinical-trial-weight-loss-result<\/a>. Last accessed: February 2024.<\/p>\n<p><sup>2<\/sup>Boehringer Ingelheim. Top-line Results From A Study to Test Efficacy of BI456906 in Adults With Non-alcoholic Steatohepatitis (NASH) and Fibrosis (F1-F3). Data on file.<\/p>\n<p><sup>3<\/sup>Younossi, Z.M., et al. Global epidemiology of nonalcoholic fatty liver diseaseMeta-analytic assessment of prevalence, incidence, and outcomes.\u00a0<em>Hepatology<\/em>, 2016; 64: 73-84.\u00a0<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=Rn_XD3LjfnRhRTY-r54hzY4QzNvdXp2wgo_WyB93HqmUttO7A31T4sQCMU4r1QMrnxWrKWd8h6YbayF2pnd4ycNvcAJMDawd_y9_WPXnBQxXV5MdleYucoanrCvS7U6VriUr22owtph3zP74luu7YN9vpDJA_oF8Om1Zdif7LxcGpwYAD81M_tKiLZQjd_ZigOsJyCQcppQfIf5wylkjnMtZrtZBzH7bj9Fl6a2pK3A=\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1002\/hep.28431<\/a><\/p>\n<p><sup>4<\/sup>Godoy-Matos AF, Silva J\u00fanior WS, Valerio CM. NAFLD as a continuum: from obesity to metabolic syndrome and diabetes.\u00a0<em>Diabetol Metab Syndr.<\/em>\u00a02020 Jul 14;12:60. doi: 10.1186\/s13098-020-00570-y.\u00a0<\/p>\n<p><sup>5<\/sup>Tesfay M, Goldkamp WJ, Neuschwander-Tetri BA. NASH: The Emerging Most Common Form of Chronic Liver Disease.\u00a0<em>Mo Med.\u00a0<\/em>2018 May-Jun;115(3):225-229.<\/p>\n<p><sup>6<\/sup>Musso G, et al. Association of non-alcoholic fatty liver disease with chronic kidney disease: a systematic review and meta-analysis.\u00a0<em>PLoS Med.<\/em>\u00a02014 Jul 22;11(7):e1001680. doi: 10.1371\/journal.pmed.1001680.<\/p>\n<p><sup>7<\/sup>T. Zimmerman et al. BI 456906: Discovery and preclinical pharmacology of a novel GCGR\/GLP-1R dual agonist with robust anti-obesity efficacy.\u00a0<em>Molecular Metabolism<\/em>. 2022;66:101633. doi: 10.1016\/j.molmet.2022.101633.<\/p>\n<p><sup>8<\/sup>Shah M, Vella A. Effects of GLP-1 on appetite and weight.\u00a0<em>Rev Endocr Metab Disord<\/em>. 2014 Sep;15(3):181-7. doi: 10.1007\/s11154-014-9289-5.<\/p>\n<p><sup>9<\/sup>Rui L. Energy metabolism in the liver.\u00a0<em>Compr Physiol.\u00a0<\/em>2014 Jan;4(1):177-97. doi: 10.1002\/cphy.c130024<\/p>\n<p><sup>10<\/sup>British Liver Trust. International NASH Day. Available at:\u00a0<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=Rn_XD3LjfnRhRTY-r54hzc95XZcKWyloUVSgg7_CG3QxvLN5tEBB9Q3xTG06vuT02G9M_6NyHgOyTIFgK6SftESWShQFaksRWAJW1ODMa1c31FBGSTp3xlwuSesP0cHhMRd9Hd1sCZfJSdw6RoyUJ4p_w_8uh7-PQEcrMsWBsTY-ywbw22dzxGyxaxdeGPRuSyObOVaaurGmBrdp3piNF4GjVQT4puypvEmwh8jId9QsWptthCI-XHvqnp3jH4Tx\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/britishlivertrust.org.uk\/nashday\/<\/a>. Last accessed: February 2024.<\/p>\n<p><sup>11<\/sup>Ramai D, Facciorusso, et al. Progressive Liver Fibrosis in Non-Alcoholic Fatty Liver Disease.\u00a0<em>Cells<\/em>. 2021 Dec 2;10(12):3401.\u00a0doi: 10.3390\/cells10123401.<\/p>\n<p><sup>12<\/sup>Estes C, Razavi H, Loomba R, et al. Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease.\u00a0<em>Hepatology<\/em>. 2018; 67:123133. doi: 10.1002\/hep.29466.<\/p>\n<p><sup>13<\/sup>Tana C, Ballestri S, Ricci F, et al. Cardiovascular Risk in Non-Alcoholic Fatty Liver Disease: Mechanisms and Therapeutic Implications.\u00a0<em>Int J Environ Res Public Health<\/em>. 2019; 16. doi: 10.3390\/ijerph16173104.<\/p>\n<p><sup>14<\/sup>Khalil A, et al. New Developments and Challenges in Liver Transplantation.\u00a0<em>J Clin Med.<\/em>\u00a02023 Aug 27;12(17):5586. doi: 10.3390\/jcm12175586.<\/p>\n<p><sup>15<\/sup>Burra P, Becchetti C, Germani G. NAFLD and liver transplantation: Disease burden, current management and future challenges.\u00a0<em>JHEP<\/em>\u00a0<em>Rep<\/em>. 2020 Oct 9;2(6):100192. doi: 10.1016\/j.jhepr.2020.100192.<\/p>\n<p><sup>16<\/sup>Geier, A., et al. Real-World Burden of Nonalcoholic Steatohepatitis.\u00a0<em>Clin Gastroenterol Hepatol<\/em>. 2021 19: 1020-29.e7.<\/p>\n<p><sup>17<\/sup>ClinicalTrials.gov. A Study to Test Efficacy of BI456906 in Adults With Non-alcoholic Steatohepatitis (NASH) and Fibrosis (F1-F3). Available at:\u00a0<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=Rn_XD3LjfnRhRTY-r54hzYmNaBSgOpi4QXxVpxSmbFd5-NBhEI-HLuoNB7d_PEjwsBEhQc_FlZqVRvxCplcpqVPKJg4EL65h6U2KBxJRokro7eJd_05SU-hYqG49uuLrefkD9OXO6NEIR9akWwIWE1L9koQ7Nyduhx-FVDco-g0VCcGcbLRSuhLuZlB03p_wzPoTijgCOskOp1XSfsyrH7gyZTkotGIGUokW-yCdfUtub68S6iZO5WuS_Rd8rs-ijZ5zoUUDXCgiQfux8ycggMPRf6bwK-EQiPeyXJF-bLE=\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/classic.clinicaltrials.gov\/ct2\/show\/NCT04771273<\/a>. Last accessed: February 2024.<\/p>\n<p><sup>18<\/sup>Boehringer Ingelheim. Boehringer Ingelheim and Zealand Pharma Received FDA Fast Track Designation for Investigational Treatment for NASH. Available at:\u00a0<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=Rn_XD3LjfnRhRTY-r54hzTChANfs7agjFqmkrByqZ1fRWH8PYRxQGxKhqmzaGpYda64Hj4HpBgjry5YNVbavqc7u_LPsnVsP7ZrmGoln-KwwNV_W1g_EZS6bO-pCYXxEy545V_ghnzbRdOjv5L-geXtWwCC-GlqKQTh7LJdd6FJicGYw1MtIdZlUJWtt_4NNaRjSezJQouavfja9nz0DmNWojw1BPUQ_EvtjEpZJcYYdhF9jLhZoZNr4GH_jxDzr4D_NN1LFx8NPRD8NNAEclh6ksVeG7Pe7FkCTIA0Vi_PBUvyQsq7PB1KdbRS6SSXpa4yg4ihAUMP4-tJjRZmV9VKQl4xUgSpGEg1WzZU-0WNmNevC_wB1AO3DKDqPyBXa\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/www.boehringer-ingelheim.com\/us\/press-release\/boehringer-ingelheim-and-zealand-pharma-receive-fda-fast-track-designation<\/a>. Last accessed: January 2024.<\/p>\n<p><sup>19<\/sup>European Medicines Agency. December 2023. List of medicines currently in PRIME scheme. Available at:\u00a0<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=Rn_XD3LjfnRhRTY-r54hzbYXKwycY3LTV3dqeyff48iJw6kCrLZj87OrzonSKZPFaMqSKK1b1TrJQjZ54feez4iznA79aU8z_OwXL-5C4C3TkJ988bo230qixPyCFyNvRgtfdsj-w6xyZlOa4t182sNm9WF_ZYP4CT3UpxyIVvagqqTEllq5AA1_--orqdlzp7RpebZA_-nMbj8ekIBfOoCfOZwEEe06fNbTcJ1spsYntpzGSKiMcGdZ0Nx3TpzQh6SJDkuVdm8AcB1Wf5fdeRC69BG9fELZHSvR8Wx5skWS4nxOHuGUBIyynJto6oh-mZN5QLasaeO4b3lebfK66YRQDz5P3JSEG8apQUzILIRV86Ei9rxkUZIhPoBTGfSN\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/www.ema.europa.eu\/en\/documents\/other\/list-medicines-currently-prime-scheme_en.xlsx<\/a>. Last accessed: February 2024.<\/p>\n<p><sup>20<\/sup>Phase III studies to investigate survodutide for people living with obesity and overweight, with and without diabetes, cardiovascular disease and chronic kidney disease. Available at\u00a0<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=Rn_XD3LjfnRhRTY-r54hzTChANfs7agjFqmkrByqZ1fRWH8PYRxQGxKhqmzaGpYdyNiYEH0hpqv_q557P8lVotEltjEl-PH09o_PRzGYhRZD9az62nzT7AEjWfgV524LQGt5-EWRJZWvR_KfhYkMJxADDAS2aDutux1-iqFJRKf1bU6SSPjvSKqQw09H3sZVzHNSa9Y6mhZ-mCwKALAjvd9B3_tjig_sMKIPs5ay9sKs1ReHxx5up2Nihq4gPXYYDHAxxG3g7O1aeA2cWshZjA==\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/www.boehringer-ingelheim.com\/phase-3-studies-survodutide-obesity-and-overweight<\/a>. Last accessed: February 2024.<\/p>\n<p><sup>21<\/sup>Clinicaltrials.gov. A Study to Test Whether BI 456906 Helps Japanese People Living With Obesity Disease (SYNCHRONIZEJP). 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Non-alcoholic fatty liver disease (NAFLD). Available at:\u00a0<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=Rn_XD3LjfnRhRTY-r54hzXsmPAeulvcEZGLAewgEFSZzFsSmD5f7YAqTVtkkLsJFX7KG9kFbLV0f1gFEJJq43Kvaj5G3DMhsl0svibPPqV_jVRGrwHvAWRctHpBp9ctWfVrHDZF5ZDn0HDWipBT5cwYrU5-Yr6sh92IoBK2bTUUwM1kvd75rNmwVPkheVBJSuhMraBDlCrNd73RumEgNkRhURhTnB4eRVLtL-acY9n8BTR560RVuqwZ6NyCOmnKxAiRqV-AsBDeRuq-g9OZgmagwEP6xulEbryuLCsHjrFg=\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/www.nhs.uk\/conditions\/non-alcoholic-fatty-liver-disease<\/a>. Last accessed: January 2024.<\/p>\n<p><sup>32<\/sup>Vanderbeck S, et al. Automatic quantification of lobular inflammation and hepatocyte ballooning in nonalcoholic fatty liver disease liver biopsies.\u00a0<em>Hum Pathol.<\/em>\u00a02015 May;46(5):767-75. doi: 10.1016\/j.humpath.2015.01.019.<\/p>\n<p><sup>33<\/sup>Caldwell S, et al. Hepatocellular ballooning in NASH.\u00a0<em>J Hepatol<\/em>. 2010 Oct;53(4):719-23. doi: 10.1016\/j.jhep.2010.04.031..<\/p>\n<p><sup>34<\/sup>Clinicaltrials.gov. A Study to (1) Compare How\u00a0BI\u00a0456906\u00a0is Taken up in the Body of Healthy People and People With Liver Problems and (2) Find Out How People With Overweight and Obesity, With and Without Liver Problems, Tolerate Different Doses of\u00a0BI\u00a0456906. Available at:\u00a0<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=Rn_XD3LjfnRhRTY-r54hzdiK7ZFm8d3PchWPoXDheAaLR-n04ebZPmIr4t4uZrp_iadGvhGKbszzTRZI1QHiLrTR_xkI2R8SUIZ7qpDRYcDH9hi9NcYndYl411P8o9rlobrD6SRpsvpKDyf0X2YYJwskHfR9jjR1lwmu3Xr0zfx0Er_pUXQ-cmeHqVslCOOLTlPUeRLyu57pJdsR3Cq5lexeOb22BhPOyGxMX4XcKC3en-56lendcJfnuE4QolJn\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/clinicaltrials.gov\/study\/NCT05296733<\/a>. Last accessed: February 2024.<\/p>\n<\/p>\n<p> <img decoding=\"async\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=MTAwMDkyNTYwOSM0MDE3NzM1ODUjMjIwNTExMQ==\" \/> <br \/><img decoding=\"async\" src=\"https:\/\/ml-eu.globenewswire.com\/media\/YThkZGFkODYtMTI1Mi00ZDFiLTk1NDAtOGU3ZDBkZTUyODRjLTEyMTY2NjQ=\/tiny\/Boehringer-Ingelheim.png\" \/><br \/>\n<a href=\"https:\/\/www.globenewswire.com\/NewsRoom\/AttachmentNg\/f121dfae-77e7-4a01-b1ef-6b757767ddab\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/ml-eu.globenewswire.com\/media\/f121dfae-77e7-4a01-b1ef-6b757767ddab\/small\/111boehringer-ingelheim-logo-rgb-dark-green-002-png.png\" border=\"0\" width=\"150\" height=\"46\" alt=\"Primary Logo\" \/><\/a><\/p>\n<p>A <b>OESP<\/b> nao e(sao) responsavel(is) por erros, incorrecoes, atrasos ou quaisquer decisoes tomadas por seus clientes com base nos Conteudos ora disponibilizados, bem como tais Conteudos nao representam a opiniao da <b>OESP<\/b> e sao de inteira responsabilidade da <b>GlobeNewswire<\/b><\/p>\n","protected":false},"excerpt":{"rendered":"Boehringer Ingelheim Survodutide has potential to become best-in-class treatment for metabolic dysfunction-associated steatohepatitis (MASH)*, after meeting its primary and key secondary endpoint","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[34],"tags":[],"class_list":["post-89153","post","type-post","status-publish","format-standard","hentry","category-releases-geral"],"acf":[],"_links":{"self":[{"href":"https:\/\/bluestudio.estadao.com.br\/agencia-de-comunicacao\/wp-json\/wp\/v2\/posts\/89153","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bluestudio.estadao.com.br\/agencia-de-comunicacao\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bluestudio.estadao.com.br\/agencia-de-comunicacao\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bluestudio.estadao.com.br\/agencia-de-comunicacao\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bluestudio.estadao.com.br\/agencia-de-comunicacao\/wp-json\/wp\/v2\/comments?post=89153"}],"version-history":[{"count":0,"href":"https:\/\/bluestudio.estadao.com.br\/agencia-de-comunicacao\/wp-json\/wp\/v2\/posts\/89153\/revisions"}],"wp:attachment":[{"href":"https:\/\/bluestudio.estadao.com.br\/agencia-de-comunicacao\/wp-json\/wp\/v2\/media?parent=89153"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bluestudio.estadao.com.br\/agencia-de-comunicacao\/wp-json\/wp\/v2\/categories?post=89153"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bluestudio.estadao.com.br\/agencia-de-comunicacao\/wp-json\/wp\/v2\/tags?post=89153"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}