{"id":102368,"date":"2024-10-29T07:12:00","date_gmt":"2024-10-29T10:12:00","guid":{"rendered":"https:\/\/bluestudio.estadao.com.br\/agencia-de-comunicacao\/prnewswire\/prnewsbrasil\/descoberta-de-associacoes-de-risco-de-cancer-para-seis-novos-genes\/"},"modified":"2024-10-29T07:12:00","modified_gmt":"2024-10-29T10:12:00","slug":"descoberta-de-associacoes-de-risco-de-cancer-para-seis-novos-genes","status":"publish","type":"post","link":"https:\/\/bluestudio.estadao.com.br\/agencia-de-comunicacao\/prnewswire\/prnewsbrasil\/descoberta-de-associacoes-de-risco-de-cancer-para-seis-novos-genes\/","title":{"rendered":"Descoberta de associa\u00e7\u00f5es de risco de c\u00e2ncer para seis novos genes"},"content":{"rendered":"<p><b>PR NEWSWIRE<\/b><\/p>\n<div class=\"xn-content\">\n<span class=\"legendSpanClass\"><span class=\"xn-location\">REYKJAVIK<\/span>, Isl\u00e2ndia<\/span>, <span class=\"legendSpanClass\">29 de outubro de 2024<\/span> \/PRNewswire\/&#8211; Os cientistas da deCODE genetics\/Amgen e seus colaboradores descobriram seis novos genes com variantes raras da linha germinativa que se associam ao risco de c\u00e2ncer. Os resultados s\u00e3o publicados hoje na Nature Genetics sob o t\u00edtulo &#8220;Gene-based burden tests of rare germline variants identify six cancer\u00a0susceptibility genes&#8221;.<\/p>\n<div id=\"prni_dvprnevid0325left\" dir=\"ltr\" style=\"width: 100%;text-align: left\" title=\"Kari Stefansson senior author of the paper, ?Gene-based burden tests of rare germline variants identify six cancer susceptibility genes?, published today in Nature Genetics, discusses the paper with Erna V. Ivarsdottir first author on the paper.\"><\/div>\n<p>Um subconjunto de c\u00e2nceres surge em indiv\u00edduos que nascem com variantes de sequ\u00eancia raras que alteram significativamente seu risco de c\u00e2ncer. A descoberta de tais variantes, como as dos genes <i> BRCA1<\/i>&#8211; e <i> BRCA2<\/i>, levou a uma melhor detec\u00e7\u00e3o precoce do c\u00e2ncer e ao desenvolvimento de terapias direcionadas, reduzindo a carga do c\u00e2ncer e melhorando o progn\u00f3stico daqueles portadores dessas muta\u00e7\u00f5es.<\/p>\n<p>Neste estudo, os cientistas analisaram tr\u00eas grandes conjuntos de dados gen\u00e9ticos de indiv\u00edduos de ascend\u00eancia europeia, incluindo 130.991 pacientes com c\u00e2ncer e 733.486 controles. Atrav\u00e9s de uma an\u00e1lise de associa\u00e7\u00e3o de carga baseada em genes em 22 tipos diferentes de c\u00e2ncer, eles encontraram quatro novos genes associados ao risco de desenvolver c\u00e2ncer; o <i> BIK<\/i> pr\u00f3-apopt\u00f3tico para c\u00e2ncer de pr\u00f3stata, a autofagia envolveu <i> ATG12 <\/i> para c\u00e2ncer colorretal, <i> TG<\/i> para c\u00e2ncer de tireoide e <i> CMTR2 <\/i> para c\u00e2ncer de pulm\u00e3o e melanoma cut\u00e2neo. O aumento relativo no risco de c\u00e2ncer conferido por essas variantes foi substancial (90-295%), mas deve-se notar que o design do estudo n\u00e3o permite uma avalia\u00e7\u00e3o precisa do risco absoluto de c\u00e2ncer ao longo da vida.<\/p>\n<p>Al\u00e9m disso, os pesquisadores encontraram os primeiros genes com variantes raras que est\u00e3o associadas a uma diminui\u00e7\u00e3o do risco de c\u00e2ncer. Especificamente, descobriu-se que a perda de <i> AURKB<\/i> protege contra qualquer tipo de c\u00e2ncer, e a perda de <i> PPP1R15A<\/i> foi associada a um risco 53% menor de c\u00e2ncer de mama. Isso sugere que a inibi\u00e7\u00e3o de <i> PPP1R15A<\/i> pode ser uma op\u00e7\u00e3o terap\u00eautica para c\u00e2ncer de mama.<\/p>\n<p>O estudo revelou novos insights sobre os mecanismos biol\u00f3gicos envolvidos na predisposi\u00e7\u00e3o ao c\u00e2ncer que, esperamos, levar\u00e3o a melhores estrat\u00e9gias de triagem e tratamento.<\/p>\n<p>V\u00eddeo &#8211; <a href=\"https:\/\/mma.prnewswire.com\/media\/2541696\/deCODE_Genetics.mp4\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/mma.prnewswire.com\/media\/2541696\/deCODE_Genetics.mp4<\/a><br \/>Foto &#8211; <a href=\"https:\/\/mma.prnewswire.com\/media\/2540476\/deCODE_genetics.jpg\" target=\"_blank\" rel=\"nofollow noopener\"> https:\/\/mma.prnewswire.com\/media\/2540476\/deCODE_genetics.jpg<\/a><\/p>\n<p>\u00a0<\/p>\n<div id=\"prni_dvprnejpg770eleft\" dir=\"ltr\" style=\"width: 100%;text-align: left\"><img decoding=\"async\" id=\"prnejpg770eleft\" title=\"Kari Stefansson CEO of deCODE genetics and senior author on the paper in Nature Genetics, with Erna V. Ivarsdottir scientists at deCODE genetics and first author.\" src=\"https:\/\/mma.prnewswire.com\/media\/2540476\/deCODE_genetics.jpg\" alt=\"Kari Stefansson CEO of deCODE genetics and senior author on the paper in Nature Genetics, with Erna V. Ivarsdottir scientists at deCODE genetics and first author.\" align=\"middle\" \/><\/div>\n<p>\u00a0<\/p>\n<p id=\"PURL\"><img loading=\"lazy\" decoding=\"async\" title=\"Cision\" width=\"12\" height=\"12\" alt=\"Cision\" src=\"https:\/\/c212.net\/c\/img\/favicon.png?sn=PT40303&amp;sd=2024-10-29\" \/> View original content:<a id=\"PRNURL\" rel=\"nofollow noopener\" href=\"https:\/\/www.prnewswire.com\/br\/comunicados-para-a-imprensa\/descoberta-de-associacoes-de-risco-de-cancer-para-seis-novos-genes-302288445.html\" target=\"_blank\">https:\/\/www.prnewswire.com\/br\/comunicados-para-a-imprensa\/descoberta-de-associacoes-de-risco-de-cancer-para-seis-novos-genes-302288445.html<\/a><\/p>\n<p>FONTE  deCODE genetics<\/p>\n<\/div>\n<p><img decoding=\"async\" alt=\"\" src=\"https:\/\/rt.prnewswire.com\/rt.gif?NewsItemId=PT40303&amp;Transmission_Id=202410290600PR_NEWS_LATAM____PT40303&amp;DateId=20241029\" style=\"border:0px;width:1px;height:1px\" \/><\/p>\n<p>A <b>OESP<\/b> n\u00e3o \u00e9(s\u00e3o) respons\u00e1vel(is) por erros, incorre\u00e7\u00f5es, atrasos ou quaisquer decis\u00f5es tomadas por seus clientes com base nos Conte\u00fados ora disponibilizados, bem como tais Conte\u00fados n\u00e3o representam a opini\u00e3o da <b>OESP<\/b> e s\u00e3o de inteira responsabilidade da <b>PR Newswire Ltda<\/b><\/p>\n","protected":false},"excerpt":{"rendered":"REYKJAVIK, Isl\u00e2ndia, 29 de outubro de 2024 \/PRNewswire\/&#8211; Os cientistas da deCODE genetics\/Amgen e seus colaboradores descobriram seis novos genes com variantes raras da linha ger","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[28],"tags":[],"class_list":["post-102368","post","type-post","status-publish","format-standard","hentry","category-prnewsbrasil"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - 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